https://newatlas.com/medical/fat-cancer ... une-cells/eli taman mukaan syopasolut kayttavat rasvaa hyvakseen ja rasva lamauttaa immuunisoluja. Lihavat hiiret tutkimuskohteena.
In the new study, Harvard researchers found that high-fat diets seem to reduce the amount of CD8+ T cells, as well as their cancer-fighting abilities. When fat is more readily available, tumors will rewire their metabolism to gobble it up. The high energy content accelerates their growth, while at the same time depriving T cells of fuel which they would otherwise use to fight cancer.
“We now know there is a metabolic tug-of-war between T cells and tumor cells that changes with obesity,” says Arlene Sharpe, co-senior author of the study. “Our study provides a roadmap to explore this interplay, which can help us to start thinking about cancer immunotherapies and combination therapies in new ways.”
They found that tumors grew much faster in the obese mice, but interestingly, that only applied to mice with immunogenic cancers – those that the immune system responds to more readily.
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